Computational Drug Screening in COVID-19 Drug Repurposing Research: Encouraging Findings and Limitations
نویسندگان
چکیده
منابع مشابه
A novel computational approach for drug repurposing using systems biology.
Motivation Identification of novel therapeutic effects for existing U.S. Food and Drug Administration (FDA)-approved drugs, drug repurposing, is an approach aimed to dramatically shorten the drug discovery process, which is costly, slow and risky. Several computational approaches use transcriptional data to find potential repurposing candidates. The main hypothesis of such approaches is that if...
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1 European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), The Genome Campus, Hinxton, Cambridge CB10 1SD, UK; 2 Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK 3 Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931 Cologne, Germany $ current address: M...
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In the mid-1980s, a French company geared its efforts toward developing a synthetic steroid capable of blocking the glucocorticoid receptor in order to potentially treat Cushing’s syndrome. Preclinical studies revealed that the compound developed, termed RU-38486, was indeed a potent antiglucocorticoid agent [1], yet with a caveat: if given to pregnant animals, it terminated pregnancy [2-4]. Th...
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Infectious diseases account for nearly one fifth of the worldwide death toll every year. The continuous increase of drug-resistant pathogens is a big challenge for treatment of infectious diseases. In addition, outbreaks of infections and new pathogens are potential threats to public health. Lack of effective treatments for drug-resistant bacteria and recent outbreaks of Ebola and Zika viral in...
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ژورنال
عنوان ژورنال: Journal of exploratory research in pharmacology
سال: 2022
ISSN: ['2572-5505']
DOI: https://doi.org/10.14218/jerp.2021.00061